The Synergy of combining TMS and ketamine
Standard rTMS (repetitive transcranial magnetic stimulation) and Spravato©/ketamine are valuable tools, but they often act in isolation. Our invention co-administers these therapies to "prime and pulse" the brain, creating a durable network reset.
Figure 1: Improved brain function during a course of TMS + ketamine treatments as shown by imaging blood use in the brain (perfusion).
We pioneered the timing and sequence required to maximize neuroplasticity. By delivering TMS while the brain is in a "plastic window" from ketamine, we steer neural activity toward healthier patterns.
The "Prime & Pulse" Methodology
15+ YEARSDATA
"This treatment maximizes the benefits of both rTMS and ketamine while offering long lasting relief."
The Prime
1
Ketamine opens the window of neuroplasticity by increasing BDNF, a protein that enables neurological change.
The Pulse
2
Precision-directed rTMS pulses "steer" this plasticity into functional networks.
The Stabilization
3
The combination takes the plasticity + the healthier patterns and stabilizes them in the brain for long-term recovery.
Diagnostics
4
We use Brain-Network Informed diagnostics to ensure precise protocol placement.
A Paradigm Shift in Precision Psychiatry
Understanding how our innovative treatment compares to conventional FDA-cleared
monotherapies.
Feature
Standard rTMS (repetitive
transcranial magnetic stimulation)
Mechanism
Localized magnetic stimulation.
Brain Connectivity
Targeted to Prefrontal Cortex.
Spravato©/ketamine
Our Invention: TMS+Ketamine
Glutamate receptor nasal
spray.
Simultaneous magnetic & chemical modulation.
Systemic chemical impact.
Resets Salience & Executive Networks.
Clinical Evidence & Scientific Foundations
Our innovative treatment has been peer-reviewed and published in leading journals. We focus on Thalamocortical Dysrhythmia—using imaging biomarkers like SPECT to visualize perfusion and recalibrate brain networks.
Conceptualizing the "Network Reset"
*SUD = Substance Use Disorder
Psychiatric Times (2026)
Psychiatric Times (2025)
Frontiers in Psychiatry (2022)
Information for Referral Sources
Clinicians seeking advanced interventions for refractory patients: we offer a collaborative approach. Our protocols address co-morbidities of mood, pain, and substance over-use.
Why Refer to Us?
Proprietary Combined Synergy Protocol
Specialize in preventing/treating stubborn psychiatric suffering
Evidence-backed (Psychiatric Times, Frontiers)