The Neuroscience Center
TRD Subtyping Rosetta Stone & Clinical Masterclass
Understanding Your Unique Brain Circuit Pattern
If standard antidepressants or talk therapy haven't given you full relief, it isn't a failure of effort or willpower. Modern neuroscience proves that depression stems from localized disruptions in specific brain circuits. Personality traits (like worry or low motivation) are often the enduring behavioral manifestations of these underlying brain firing patterns.
Correcting Circuit Dysfunction with TMS & Ketamine to Enable Integrative Care
When a neural circuit is locked in refractory failure, talk therapy, lifestyle changes, and supplements hit a biological wall. Combination TMS and Ketamine therapy corrects this root dysfunction: Ketamine triggers rapid synaptogenesis (opening a 48–72 hour neuroplasticity window), while 1 Hz Fz TMS acts as an architectural guide to calm hyperactive threat loops or rebuild working memory connectivity.
With the underlying circuit desynchronization repaired, the patient is biologically freed from refractory resistance. This enables the brain to absorb and respond to modern integrative psychiatry—including psychotherapy, naturopathic supplementation, circadian tuning, and lifestyle habits—for sustained long-term wellness.
Dual Intake Questionnaire & Score Alignment
Rate behaviors over the past 3–6 months on a scale of 0 (Never) to 3 (Constantly).
Biotype Score Radar Comparison
Patient Self-Report (Teal) vs. Informant Observation (Amber)
Clinical Alignment & Pattern Analysis
Automated concordance matching and discrepancy flags.
Complete the questionnaire to view automated score alignment and clinical analysis.
The Multi-Paradigm Scientific Crosswalk Grid
Cross-referencing Salvadore, Pizzagalli Models #1 & #2, Stanford fMRI Biotypes (Williams 2017), Chinese LPA Cohort (2019), Cloninger TCI Temperament/Character, Immuno-Metabolic Axis (BBI 2025), and DSM-5 Phenotypes across 4 primary core neural domains.
| Core Neural Domain & Stratification Task | 1. Salvadore Model (2010) | 2. Pizzagalli Models #1 & #2 | 3. Stanford fMRI Model | 4. Chinese LPA Model | 5. Cloninger TCI Temperament | 6. Immuno-Metabolic (BBI 2025) | 7. Integrative Interventions | 8. DSM-5 Phenotype | Target Rescue Goal |
|---|
Foundational Scientific References & Article Request Portal
Peer-reviewed literature validating neurobehavioral biotyping, Cloninger TCI personality crosswalks, task stratification, and combination TMS/Ketamine therapy.
Patient & Family Care Roadmap
Integrated intake summary, family commitments, and integrative care plan.
The Neuroscience Center
Precision Interventional Psychiatry & Neurobehavioral Biotyping
Biotype Score Summary & Cloninger TCI Crosswalk
| Neurobehavioral Biotype | Patient Score (0-9) | Informant Score (0-9) | Cloninger TCI Alignment | Primary Actionable Support Focus |
|---|---|---|---|---|
| 1. Cognitive Dyscontrol (CCN) | 0/9 | 0/9 | Low Persistence (PS) / Low Self-Directedness | Scaffold task planning; offer single-step guidance |
| 2. Negative Affect Loop (Salience) | 0/9 | 0/9 | High Harm Avoidance (HA1: Worry / HA2: Uncertainty) | De-escalate stress; provide calm, neutral grounding |
| 3. Anhedonia / Reward Blunt | 0/9 | 0/9 | Low Novelty Seeking (NS) & Low Reward Dependence | Low-demand participation; remove pressure for joy |
| 4. Central Executive Atrophy | 0/9 | 0/9 | Low Persistence (PS) + High Asthenic Fatigue (HA4) | Pace cognitive energy; enforce mandatory rest breaks |
Integrative Pharmacological & Naturopathic Care Checklist
Modafinil / Guanfacine / Memantine consideration + Citicoline 500mg daily & Bacopa monnieri extract.
Low-dose non-SSRI anxiolytic tuning + Standardized Saffron (30mg) & Magnesium L-Threonate.
Bupropion / Pramipexole / LDN consideration + L-Tyrosine (500mg) & Rhodiola rosea.
IV NAD+ Infusion therapy / Stimulant tuning + Lion's Mane, Creatine 5g, & CoQ10/PQQ.
Agreed Support Commitments
No elevated scores detected. Complete questionnaire to populate commitments.
Patient / Loved One Signature
The Neuroscience Center Clinician