The Synergy of combining TMS and ketamine
Standard rTMS (repetitive transcranial magnetic stimulation) and Spravato©/ketamine are valuable tools, but they often act in isolation. Our invention co-administers these therapies to "prime and pulse" the brain, creating a durable network reset.
Figure 1: Improved brain function during a course of TMS + ketamine treatments as shown by imaging blood use in the brain (perfusion).
The "Prime & Pulse" Methodology
We pioneered the timing and sequence required to maximize neuroplasticity. By delivering TMS while the brain is in a "plastic window" from ketamine, we steer neural activity toward healthier patterns.
15+ YEARS DATA
"This treatment maximizes the benefits of both rTMS and ketamine while offering long lasting relief."
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The Prime
Ketamine opens the window of neuroplasticity by increasing BDNF, a protein that enables neurological change.
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The Pulse
Precision-directed rTMS pulses "steer" this plasticity into functional networks.
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Diagnostics
We use Brain-Network Informed diagnostics to ensure precise protocol placement.
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The Stabilization
The combination takes the plasticity + the healthier patterns and stabilizes them in the brain for long-term recovery.
A Paradigm Shift in Precision Psychiatry
Understanding how our innovative treatment compares to conventional FDA-cleared
monotherapies.
Feature
Standard rTMS (repetitive transcranial magnetic stimulation)
Spravato©/ketamine
Our Invention: TMS+Ketamine
Mechanism
Localized magnetic stimulation.
Glutamate receptor nasal spray.
Simultaneous magnetic & chemical
modulation.
Brain Connectivity
Targeted to Prefrontal Cortex.
Systemic chemical impact.
Resets Salience & Executive Networks.
Clinical Evidence & Scientific Foundations
Our innovative treatment has been peer-reviewed and published in leading journals. We focus on Thalamocortical Dysrhythmia—using imaging biomarkers like SPECT to visualize perfusion and recalibrate brain networks.
Conceptualizing the "Network Reset"
Psychiatric Times (2026)
A Network-Based Approach to Depression, Neuropathic Pain, and SUD Using Coadministered TMS and ketamine.
Psychiatric Times (2025)
What’s Perfusion Got to Do With It? (Best & Pavel)
Frontiers in Psychiatry (2022)
Brain SPECT as an Imaging Biomarker for Evaluating Effects of Novel Treatments in Psychiatry.
Proprietary Combined Synergy Protocol
Information for Referral Sources
Clinicians seeking advanced interventions for refractory patients: we offer a collaborative approach. Our protocols address co-morbidities of mood, pain, and substance over-use.
Why Refer to Us?